Number of the records: 1
Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids
- 1.0567779 - BC 2023 RIV GB eng J - Journal Article
Gahura, Ondřej - Chauhan, Prashant - Zíková, Alena
Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids.
Trends in Parasitology. Roč. 38, č. 12 (2022), s. 1053-1067. ISSN 1471-4922. E-ISSN 1471-5007
R&D Projects: GA ČR(CZ) GJ20-04150Y; GA MŠMT(CZ) EF16_019/0000759
Institutional support: RVO:60077344
Keywords : assembly factor * biogenesis * mitochondrial ribosomes * mitoribosomes * Trypanosoma
OECD category: Biochemistry and molecular biology
Impact factor: 9.6, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1471492222001878?via%3Dihub
Translation in mitochondria is mediated by mitochondrial ribosomes, or mitoribosomes, complex ribonucleoprotein machines with dual genetic origin. Mitoribosomes in trypanosomatid parasites diverged markedly from their bacterial ancestors and other eukaryotic lineages in terms of protein composition, rRNA content, and overall architecture, yet their core functional elements remained conserved. Recent cryo-electron microscopy studies provided atomic models of trypanosomatid large and small mitoribosomal subunits and their precursors, making these parasites the organisms with the best-understood biogenesis of mitoribosomes. The structures revealed molecular mechanisms and players involved in the assembly of mitoribosomes not only in the parasites, but also in eukaryotes in general.
Permanent Link: https://hdl.handle.net/11104/0339044
Number of the records: 1