MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker

0567756 - ÚEM 2023 RIV NL eng J - Journal Article
Červená, Klára - Vodenková, Soňa - Vymetálková, Veronika
MALAT1 in colorectal cancer: Its implication as a diagnostic, prognostic, and predictive biomarker.
Gene. Roč. 843, aug (2022), č. článku 146791. ISSN 0378-1119. E-ISSN 1879-0038
R&D Projects: GA MZd(CZ) NU22J-03-00033; GA ČR(CZ) GA22-05942S
Institutional support: RVO:68378041
Keywords : lncRNA * ceRNA * MALAT1 * biomarker * colorectal cancer
OECD category: Cell biology
Impact factor: 3.5, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/abs/pii/S0378111922006102?via%3Dihub

Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1), originally described as a prognostic biomarker remarkably linked with metastasis potential in lung cancer, has been identified as contributing to many diseases, including colorectal cancer (CRC). This long non-coding RNA (lncRNA) has come to the forefront of lncRNA research for its implications in cancer-related processes, such as cell proliferation and migration. In general, lncRNAs are recognized as enhancers, scaffolds, or decoys for a variety of oncogenes and tumor sup-pressors, although our understanding of lncRNA functions and mechanisms of action is still limited. Nowadays, cancer research is attracted to lncRNAs' ability to improve the early diagnosis of cancer, determine patients' prognosis, or predict therapy outcomes. In this review, we aimed to evaluate recent publications trying to un-cover the cellular mechanisms of MALAT1-mediated regulation, and its potential exploitation in the management of CRC. The conclusions of this review provide robust support for the essential role of MALAT1 in CRC devel-opment and future personalized therapy.
Permanent Link: https://hdl.handle.net/11104/0339004