Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids

0567543 - ÚOCHB 2024 RIV CH eng J - Journal Article
Szczurowska, Ewa - Szánti-Pintér, Eszter - Chetverikov, Nikolai - Randáková, Alena - Kudová, Eva - Jakubík, Jan
Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids.
International Journal of Molecular Sciences. Roč. 24, č. 1 (2023), č. článku 507. E-ISSN 1422-0067
R&D Projects: GA MŠMT(CZ) LX22NPO5107
Institutional support: RVO:61388963 ; RVO:67985823
Keywords : neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * Alzheimer's disease * Parkinson's disease * schizophrenia * substance abuse * depression
OECD category: Neurosciences (including psychophysiology; Physiology (including cytology) (FGU-C)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms24010507

Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.
Permanent Link: https://hdl.handle.net/11104/0338789