Structure-property correlation studies of cross-linked citric acid-based elastomers

0567520 - FGÚ 2023 RIV PL eng J - Journal Article
Koper, F. - Świergosz, T. - Zaba, A. - Flis, A. - Trávníčková, Martina - Bačáková, Lucie - Pamula, E. - Bogdal, D. - Kasprzyk, W.
Structure-property correlation studies of cross-linked citric acid-based elastomers.
Engineering of Biomaterials. Roč. 24, č. 163 (2021), s. 45-45. ISSN 1429-7248.
[Conference Biomaterials in Medicine and Veterinary Medicine /30./. Rytro, 14.10.2021-17.10.2021]
R&D Projects: GA ČR(CZ) GA21-06065S
Institutional support: RVO:67985823
Keywords : elastomers * biomaterials * poly(alkylene citrate) (PAC) biomaterials
OECD category: Biomaterials (as related to medical implants, devices, sensors)
Method of publishing: Open access
http://www.biomaterials.pl/Issue-Special%20Issue%20163-2021,10425

In recent years, poly(alkylene citrate) (PAC) biomaterials have become one of the most promising biomaterials for the production of scaffolds for soft tissue engineering . Moreover, they were considered as components of numerous composites and copolymers studied in a wide range of possible medical applications. In terms of mechanical properties, PAC-based materials are similar to those of human tissues and can be readily tailored to specific needs thus providing the opportunity of being adopted to a variety of bioengineering applications. In addition, cell proliferation studies indicated their remarkable biocompatibility and absence of cytotoxicity, with a significant decrease in thrombogenicity. However, challenging structural characterization of PAC prepolymers has been reported in only a few reports despite the extensive published literature , with the majority of papers showing serious incoherencies in the discussion of the reported spectroscopic results. Hence, the main focus of this work was to optimize the composition and synthesis parameters of PAC polymers based on two diols: 1,6-hexanediol or 1,8-octanediol in two comonomer molar ratios, to obtain materials with defined structure and physicochemical properties. For evaluating their suitability as biomaterials, experiments were performed with adipose tissue-derived stem cells.
Permanent Link: https://hdl.handle.net/11104/0338774