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Cu(0)-RDRP of 2-hydroxyethyl methacrylate in a non-polar solvent enables rapid synthesis of high-molecular weight homopolymers and direct access to amphiphilic copolymers
- 1.0567290 - ÚMCH 2024 RIV NL eng J - Journal Article
Gupta, Sachin - Raus, Vladimír
Cu(0)-RDRP of 2-hydroxyethyl methacrylate in a non-polar solvent enables rapid synthesis of high-molecular weight homopolymers and direct access to amphiphilic copolymers.
Reactive and Functional Polymers. Roč. 183, February (2023), č. článku 105509. ISSN 1381-5148. E-ISSN 1873-166X
Institutional support: RVO:61389013
Keywords : 2-hydroxyethyl methacrylate * Cu-RDRP * polymerization
OECD category: Polymer science
Impact factor: 5.1, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1381514823000123?via%3Dihub
2-Hydroxyethyl methacrylate (HEMA) is an important functional monomer affording (co)polymers with numerous applications in different fields. Nevertheless, we still lack a reliable polymerization method for the synthesis of well-defined, high-molecular weight (MW) HEMA homopolymers, as well as for controlled copolymerization of unprotected HEMA with lipophilic comonomers. Herein, we report that rapid and well-controlled (co)polymerization of HEMA can be achieved via metallic copper-mediated reversible-deactivation radical polymerization (Cu(0)-RDRP) in a non-polar solvent (1,4-dioxane) using a chlorine-based initiation/catalytic system. With purified HEMA monomer, this protocol affords very well-defined (Ɖ ≤ 1.26) HEMA homopolymers in an unprecedently wide range of molecular weights from 10,000 to 500,000. Conversely, the structurally analogous bromine-based initiation/catalytic system leads to an uncontrolled polymerization. The use of a non-polar solvent enables, for the first time, a direct access to low-dispersity HEMA-rich copolymers with non-polar comonomers, including highly lipophilic ones. This is demonstrated on the successful copolymerization of HEMA with an equimolar amount of 2-ethylhexyl methacrylate and of lauryl methacrylate, yielding well-defined amphiphilic copolymers at quantitative conversion. This work significantly expands the application scope of the HEMA monomer and demonstrates for the first time that Cu(0)-RDRP in a non-polar solvent is applicable also to comparatively polar monomers.
Permanent Link: https://hdl.handle.net/11104/0338557
Number of the records: 1