NMR-BASED METABOLOMIC ANALYSIS OF BLOOD PLASMA AS A PANCREATIC CANCER DIAGNOSTIC TOOL

0566927 - ÚCHP 2023 HR eng A - Abstract
Michálková, Lenka - Horník, Štěpán - Setnička, V. - Sýkora, Jan - Bunganič, B.
NMR-BASED METABOLOMIC ANALYSIS OF BLOOD PLASMA AS A PANCREATIC CANCER DIAGNOSTIC TOOL.
Book of Abstracts. Zagreb: Croatian Chemical Society, 2022 - (Bregović, N.; Namjesnik, D.; Novak, P.; Vuković, J.). s. 61, č. článku SE-8. ISBN 978-953-8334-04-7.
[Magnetic Moments in Central Europe 2022. 01.06.2022-04.06.2022, Primošten]
R&D Projects: GA TA ČR(CZ) TK02010035
Institutional support: RVO:67985858
Keywords : blood plasma * nmr metabolomic * pancreatic cancer
OECD category: Environmental sciences (social aspects to be 5.7)

In this work, 1H NMR metabolomic analysis of blood plasma was used as an alternative approach for early PC diagnosis in RODM patients. Based on concentration profile of 58 metabolites, a discrimination of PC patients from long-term T2DM patients was achieved. A specific biomarker panel of eight metabolites was proposed and successfully tested for PC diagnosis against T2DM patients and healthy controls. Moreover, a prediction model for the identification of risk individuals for PC development in RODM group was developed and the patients likely suffering from pancreatogenic diabetes were identified. Six of 59 RODM patients had similar metabolic characteristics as PC patients and their health conditions were therefore re-examined.
The found pathological changes correlated reasonably with our findings. Recent results also indicated subtle metabolic changes among individual PC clinical stages that could be used for their differentiation in future.
Permanent Link: https://hdl.handle.net/11104/0338190