Microglia-mediated degradation of perineuronal nets promotes pain

0566878 - ÚEM 2023 RIV US eng J - Journal Article
Tansley, S. - Gu, N. - Guzman, A.U. - Cai, W. - Wong, C. - Lister, K.C. - Munoz-Pino, E. - Yousefpour, N. - Roome, R.B. - Heal, J. - Wu, N. - Castonguay, A. - Lean, G. - Muir, E.M. - Kania, A. - Prager-Khoutorsky, M. - Zhang, J. - Gkogkas, Ch.G. - Fawcett, James - Diatchenko, L. - Ribeiro-da-Silva, A. - De Koninck, Y. - Mogil, J.S. - Khoutorsky, A.
Microglia-mediated degradation of perineuronal nets promotes pain.
Science. Roč. 377, č. 6601 (2022), s. 80-86. ISSN 0036-8075. E-ISSN 1095-9203
Institutional support: RVO:68378041
Keywords : spared nerve injury * spinal-cord * neuropathic pain * chondroitinase ABC
OECD category: Neurosciences (including psychophysiology
Impact factor: 56.9, year: 2022
Method of publishing: Limited access
https://www.science.org/doi/10.1126/science.abl6773

Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets ( PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.
Permanent Link: https://hdl.handle.net/11104/0338152