Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

0565986 - ÚMG 2023 RIV CH eng J - Journal Article
Paprčková, Darina - Niederlová, Veronika - Moudrá, Alena - Drobek, Aleš - Přibíková, Michaela - Janušová, Šárka - Schober, K. - Neuwirth, Aleš - Michálik, Juraj - Huranová, Martina - Horková, Veronika - Cesneková, Michaela - Šímová, Michaela - Procházka, Jan - Balounová, Jana - Busch, D. H. - Sedláček, Radislav - Schwarzer, Martin - Štěpánek, Ondřej
Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections.
Frontiers in Immunology. Roč. 13, 6 Oct (2022), č. článku 1009198. ISSN 1664-3224. E-ISSN 1664-3224
R&D Projects: GA ČR GJ19-03435Y; GA ČR(CZ) GM21-19640M; GA MŠMT(CZ) LM2015040; GA MŠMT(CZ) LM2018126; GA MŠMT ED2.1.00/19.0395; GA MŠMT(CZ) ED1.1.00/02.0109; GA MŠMT(CZ) LX22NPO5103
Research Infrastructure: CCP - 90040; CCP II - 90126
Institutional support: RVO:68378050 ; RVO:61388971
Keywords : T cell * self-reactivity * antigen-inexperienced memory-like CD8 T cells * T-cell diversity * interferon response
OECD category: Immunology; Immunology (MBU-M)
Impact factor: 7.3, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8(+) T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naive monoclonal CD8(+) T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.
Permanent Link: https://hdl.handle.net/11104/0337427