How alternative splicing changes the properties of plant proteins

0565617 - ÚEB 2023 RIV GB eng J - Journal Article
Kashkan, Ivan - Timofeyenko, Ksenia - Růžička, Kamil
How alternative splicing changes the properties of plant proteins.
Quantitative Plant Biology. Roč. 3, Jul (2022), č. článku e14. E-ISSN 2632-8828
R&D Projects: GA MŠMT(CZ) EF16_019/0000738
Institutional support: RVO:61389030
Keywords : alternative splicing * competitive inhibition * feedback loop
OECD category: Biochemical research methods
Method of publishing: Open access
https://doi.org/10.1017/qpb.2022.9

Most plant primary transcripts undergo alternative splicing (AS), and its impact on protein diversity is a subject of intensive investigation. Several studies have uncovered various mechanisms of how particular protein splice isoforms operate. However, the common principles behind the AS effects on protein function in plants have rarely been surveyed. Here, on the selected examples, we highlight diverse tissue expression patterns, subcellular localization, enzymatic activities, abilities to bind other molecules and other relevant features. We describe how the protein isoforms mutually interact to underline their intriguing roles in altering the functionality of protein complexes. Moreover, we also discuss the known cases when these interactions have been placed inside the autoregulatory loops. This review is particularly intended for plant cell and developmental biologists who would like to gain inspiration on how the splice variants encoded by their genes of interest may coordinately work.
Permanent Link: https://hdl.handle.net/11104/0337134