Distinguishing Invasive from Chronic Pulmonary Infections: Host Pentraxin 3 and Fungal Siderophores in Bronchoalveolar Lavage Fluids\n

0565573 - MBÚ 2023 RIV CH eng J - Journal Article
Dobiáš, R. - Jaworská, P. - Skopelidou, V. - Strakoš, J. - Višňovská, D. - Káňová, M. - Škríba, Anton - Lysková, P. - Bartek, T. - Janíčková, I. - Kozel, R. - Cwiková, L. - Vrba, Z. - Navrátil, M. - Martinek, J. - Coufalová, P. - Krejčí, E. - Ulmann, V. - Raška, M. - Stevens, D. A. - Havlíček, Vladimír
Distinguishing Invasive from Chronic Pulmonary Infections: Host Pentraxin 3 and Fungal Siderophores in Bronchoalveolar Lavage Fluids
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Journal of Fungi. Roč. 8, č. 11 (2022), č. článku 1194. E-ISSN 2309-608X
R&D Projects: GA ČR(CZ) GA21-17044S
Institutional support: RVO:61388971
Keywords : invasive fungal disease * pulmonary aspergillosis * bronchoalveolar lavage fluid * pentraxin-3 * triacetylfusarinine C * non-neutropenic
OECD category: Microbiology
Impact factor: 4.7, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2309-608X/8/11/1194

The multiple forms of pulmonary aspergillosis caused by Aspergillus species are the most common respiratory mycoses. Although invasive, the analysis of diagnostic biomarkers in bronchoalveolar lavage fluid (BALF) is a clinical standard for diagnosing these conditions. The BALF samples from 22 patients with proven or probable aspergillosis were assayed for human pentraxin 3 (Ptx3), fungal ferricrocin (Fc), and triacetylfusarinine C (TafC) in a retrospective study. The infected group included patients with invasive pulmonary aspergillosis (IPA) and chronic aspergillosis (CPA). The BALF data were compared to a control cohort of 67 patients with invasive pulmonary mucormycosis (IPM), non-Aspergillus colonization, or bacterial infections. The median Ptx3 concentrations in patients with and without aspergillosis were 4545.5 and 242.0 pg/mL, respectively (95% CI, p < 0.05). The optimum Ptx3 cutoff for IPA was 2545 pg/mL, giving a sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 100, 98, 95, and 100%, respectively. The median Ptx3 concentration for IPM was high at 4326 pg/mL. Pentraxin 3 assay alone can distinguish IPA from CPA and invasive fungal disease from colonization. Combining Ptx3 and TafC assays enabled the diagnostic discrimination of IPM and IPA, giving a specificity and PPV of 100%.
Permanent Link: https://hdl.handle.net/11104/0337112