A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic)

0565424 - ARÚ 2024 RIV US eng J - Journal Article
Vargová, L. - Vymazalová, K. - Jarošová, I. - Mařík, I. - Horáčková, L. - Trampota, František - Rebay-Salisbury, K. - Rendl, B. - Kanz, F. - Zlámalová, D.
A case of congenital multiple epiphyseal dysplasia from the Late Migration Period graveyard in Drnholec (Czech Republic).
International Journal of Paleopathology. Roč. 40, March (2023), s. 33-40. ISSN 1879-9817. E-ISSN 1879-9825
Institutional support: RVO:67985912
Keywords : congenital defects * disproporcional growth * skeletal dysplasia * tooth cementum annulation (TCA) * Langobards
OECD category: Archaeology
Impact factor: 1.2, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1879981722000584?via%3Dihub

Objective: To contribute to differential diagnosis of multiple epiphyseal dysplasia (MED) in archeological and clinical contexts. Materials: A skeleton of a 30- to 45-year-old male (grave no. 806) from the Late Migration Period graveyard in Drnholec-Pod sýpkou (Czech Republic), radio-carbon dated to AD 492–530. Methods: Morphological and metric analyses. Results: Significant pathological changes were noted on ossa coxae and proximal ends of the femora, which appear similar to changes associated with Legg-Calvé-Perthes disease. X-ray examination made it possible to rule out pseudoachondroplasia, rickets and metabolic bone diseases. Conclusions: The finding was evaluated as a probable case of congenital multiple epiphyseal dysplasia. Significance: This case will contribute to the construction of estimates of the occurrence of this disease in historical populations and can be instructive for diagnostics in current medical practice. Limitations: The final diagnosis is limited by the lack of genetic analysis. Suggestion for the future research: Further clarification leading to diagnosis will benefit from genetic analysis and evaluation of skeletal remains throughout Europe.
Permanent Link: https://hdl.handle.net/11104/0336953