Current approaches to facilitate improved drug delivery to the central nervous system

0565333 - ÚOCHB 2023 RIV NL eng J - Journal Article
Markowicz-Piasecka, M. - Darłak, P. - Markiewicz, A. - Sikora, J. - Adla, Santosh Kumar - Bagina, S. - Huttunen, K. M.
Current approaches to facilitate improved drug delivery to the central nervous system.
European Journal of Pharmaceutics and Biopharmaceutics. Roč. 181, December (2022), s. 249-262. ISSN 0939-6411. E-ISSN 1873-3441
Institutional support: RVO:61388963
Keywords : drug delivery system * blood–brain barrier (BBB) * central nervous system * brain-targeted therapy * nanotechnology
OECD category: Biochemistry and molecular biology
Impact factor: 4.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.ejpb.2022.11.003

Although many pharmaceuticals have therapeutic potentials for central nervous system (CNS) diseases, few of these agents have been effectively administered. It is due to the fact that the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSF) restrict them from crossing the brain to exert biological activity. This article reviews the current approaches aiming to improve penetration across these barriers for effective drug delivery to the CNS. These issues are summarized into direct systemic delivery and invasive delivery, including the BBB disruption and convection enhanced delivery. Furthermore, novel drug delivery systems used at the nanoscale, including polymeric nanoparticles, liposomes, nanoemulsions, dendrimers, and micelles are discussed. These nanocarriers could contribute to a breakthrough in the treatment of many different CNS diseases. However, further broadened studies are needed to assess the biocompatibility and safety of these medical devices.
Permanent Link: https://hdl.handle.net/11104/0336882