Structural Properties of Deoxyfluorinated Analogues of N-acetyllactosamine, N, N'-diacetyllactosamine and, N, N'-diacetylchitobiose

0565208 - ÚCHP 2023 CZ eng A - Abstract
Kurfiřt, Martin - Dračínský, Martin - Bojarová, Pavla - Karban, Jindřich
Structural Properties of Deoxyfluorinated Analogues of N-acetyllactosamine, N, N'-diacetyllactosamine and, N, N'-diacetylchitobiose.
Book of Abstracts. 2022.
[Advances in Organic, Bioorganic and Pharmaceutical Chemistry Liblice 2022/56./. 10.11.2022-12.11.2022, Špindlerův Mlýn]
R&D Projects: GA ČR(CZ) GA20-21421S; GA MŠMT(CZ) LTC20052; GA MŠMT(CZ) LTC20072; GA ČR(CZ) GA20-01472S
Grant - others:MEYS(XE) CA18103
Institutional support: RVO:67985858 ; RVO:61388963 ; RVO:61388971
Keywords : fluorinated saccharides * lipophilicity * conformations
OECD category: Organic chemistry; Analytical chemistry (UOCHB-X); Biochemistry and molecular biology (MBU-M)

In this work, we discuss the influence of site-specific deoxyflurination of N-acetyllactosamine, N, N'-diacetyllactosamine and, N, N'-diacetylchitobiose on their physicochemical properties and on the capacity to recognize their cognate proteins.

Permanent Link: https://hdl.handle.net/11104/0336761