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Hybrid Organometallic Galectin Inhibitors
- 1.0565156 - ÚCHP 2023 CZ eng A - Abstract
Hamala, Vojtěch - Červenková Šťastná, Lucie - Karban, Jindřich
Hybrid Organometallic Galectin Inhibitors.
Book of Abstracts. 2022, č. článku P147B..
[International Conference on Organometallic Chemistry /29./. 17.07.2022-22.07.2022, Prague]
Institutional support: RVO:67985858
Keywords : galectin inhibitors * glycomimetcs * organometallic compounds * carbohydrates
OECD category: Medicinal chemistry
In this project, we replace the aromatic substituent with arene-containing organometallic structures – ferrocenes1and ruthenium arenes2 with known antitumor or antimetastatic properties. This creates a hybrid molecule that can act as both a galectin inhibitor and a cytotoxic and/or antimetastatic agent. We have confirmed that both ferrocenes and ruthenium arenes moieties are viable bioisosteric replacement for planar arenes in the context of glycomimetic galectin inhibitors. Prepared organometallic inhibitors have a comparable or even better binding affinity to galectins than their nonmetallic counterparts.
Permanent Link: https://hdl.handle.net/11104/0336663
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Number of the records: 1