The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities

0565126 - ÚMG 2023 RIV CZ eng J - Journal Article
Rašková, M. - Lacina, L. - Kejík, Z. - Venhauerová, P. - Skaličková, S. - Kolář, Michal - Jakůbek, M. - Rosel, D. - Smetana Jr., K. - Brabek, J.
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities.
Cells. Roč. 11, č. 22 (2022), č. článku 3698. E-ISSN 2073-4409
R&D Projects: GA MŠMT LX22NPO5102; GA MŠMT(CZ) EF16_019/0000785; GA MŠMT(CZ) LM2018131
Research Infrastructure: EATRIS-CZ III - 90133
Institutional support: RVO:68378050
Keywords : il-6 * cancer * metastasis
OECD category: Cell biology
Impact factor: 6, year: 2022
Method of publishing: Open access
https://www.mdpi.com/2073-4409/11/22/3698

Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential, numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
Permanent Link: https://hdl.handle.net/11104/0338503