Miniaturized liquid junction-based ESI interfaces

0565055 - ÚIACH 2023 CZ eng A - Abstract
Řemínek, Roman - Vereshchagina, E. - Vogl, A. - Václavek, Tomáš - Foret, František
Miniaturized liquid junction-based ESI interfaces.
Proceedings of APCE-CECE-ITP-IUPAC 2022. Brno: Ústav analytické chemie AV ČR, v. v. i., 2022 - (Foret, F.; Lavická, J.; Chung, D.). s. 171-171. ISBN 978-80-904959-9-9.
[APCE-CECE-ITP-IUPAC 2022. 06.11.2022-10.11.2022, Angkor Wat]
R&D Projects: GA TA ČR(CZ) TO01000232
Institutional support: RVO:68081715
Keywords : Capillary electrophoresis-mass spectrometry (CE-MS) * miniaturized ESI interface * ESI system
OECD category: Analytical chemistry

Capillary electrophoresis-mass spectrometry (CE-MS) represents a well-established hyphenated analytical technique. It has been successfully applied for many biological, pharmaceutical, environmental, and forensic applications. Among a variety of methods suitable for CE-MS coupling, electrospray ionization (ESI) is the most used. This technique provides a soft ionization of analytes with multiple charges favorable for analyses of macromolecules such as peptides, proteins, and oligosaccharides. Whereas the standard sheath liquid ESI interfaces are commercially available, the potential of nanoESI systems has not been fully explored. Due to ultralow flow rates, typically below 100 nL/min, the nanoESI technology holds a promise of superior ionization
efficiency and reduction of the ion suppression.
Permanent Link: https://hdl.handle.net/11104/0336605