Gold nanoparticles – from synthesis to extraction of biological thiols and CE-LIF analysis

0565054 - ÚIACH 2023 CZ eng A - Abstract
Dosedělová, Věra - Kubáň, Petr
Gold nanoparticles – from synthesis to extraction of biological thiols and CE-LIF analysis.
Proceedings of APCE-CECE-ITP-IUPAC 2022. Brno: Ústav analytické chemie AV ČR, v. v. i., 2022 - (Foret, F.; Lavická, J.; Chung, D.). s. 161-161. ISBN 978-80-904959-9-9.
[APCE-CECE-ITP-IUPAC 2022. 06.11.2022-10.11.2022, Angkor Wat]
R&D Projects: GA ČR(CZ) GA22-23815S
Institutional support: RVO:68081715
Keywords : CE-LIF analysis * gold nanoparticles * biothiols
OECD category: Analytical chemistry

Gold nanoparticles (AuNPs) exhibit several unique properties including redox activity, surface plasmon resonance, a high surface-to-volume ratio, or spontaneous formation of a stable Au-S dative bond with biological thiols. Biothiols are endogenous compounds that play a significant role in biological systems and their altered levels have been associated with disease states. However, levels of biothiols are low in non-invasive biological samples such as saliva or exhaled breath condensate (EBC). In this work, AuNP synthesis and AuNP-based extraction of biological thiols from samples followed by CE-LIF analysis are investigated.
Permanent Link: https://hdl.handle.net/11104/0336604