Siderophores: a potential role as a diagnostic for invasive fungal disease

0564787 - MBÚ 2023 RIV US eng J - Journal Article
Kriegl, L. - Havlíček, Vladimír - Dichtl, K. - Egger, M. - Hoenigl, M.
Siderophores: a potential role as a diagnostic for invasive fungal disease.
Current Opinion in Infectious Diseases. Roč. 35, č. 6 (2022), s. 485-492. ISSN 0951-7375. E-ISSN 1473-6527
R&D Projects: GA ČR(CZ) GA21-17044S
Institutional support: RVO:61388971
Keywords : diagnostics * invasive fungal infections * siderophores * triacetylfusarinine C
OECD category: Microbiology
Impact factor: 3.9, year: 2022
Method of publishing: Limited access
https://journals.lww.com/co-infectiousdiseases/Abstract/2022/12000/Siderophores__a_potential_role_as_a_diagnostic_for.2.aspx

Purpose of reviewInvasive fungal diseases (IFDs) such as invasive aspergillosis continue to be associated with high morbidity and mortality while presenting significant diagnostic challenges. Siderophores are high-affinity Fe3+ chelators produced by Aspergillus spp. and other fungi capable of causing IFD. Previously evaluated as a treatment target in mucormycosis, siderophores have recently emerged as new diagnostic targets for invasive aspergillosis and scedosporiosis. Here, we review the diagnostic potential of siderophores for diagnosing IFD, with a particular focus on invasive aspergillosis.Recent findingsThe major secreted siderophore of A. fumigatus, triacetylfusarinine C (TAFC), has been successfully detected by mass spectrometry in serum, BALF and urine of patients with invasive aspergillosis, with promising sensitivities and specificities in single-centre studies. Intracellular uptake of siderophores has also been utilized for imaging, wherein fungal siderophores have been conjugated with the easy-to-produce radioactive isotope gallium-68 (Ga-68) to visualize infected body sites in PET. For the Scedosporium apiospermum complex, another siderophore N(alpha)-methyl coprogen B has been shown promising as a marker for airway colonization in early studies.Siderophores and particular TAFC have the potential to revolutionize diagnostic pathways for invasive aspergillosis and other mould infections. However, larger multicentre studies are needed to confirm these promising performances. Methods that allow rapid and cost-effective measurements in routine clinical practice need to be developed, particularly when TAFC is used as a biomarker in patient specimens.
Permanent Link: https://hdl.handle.net/11104/0336378