Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice

0564730 - BFÚ 2023 RIV GB eng J - Journal Article
Perečko, Tomáš - Hoferová, Zuzana - Hofer, Michal - Perečková, Jana - Falk, Martin
Administration of nitro-oleic acid mitigates radiation-induced hematopoietic injury in mice.
Life Sciences. Roč. 310, DEC 1 2022 (2022), č. článku 121106. ISSN 0024-3205. E-ISSN 1879-0631
R&D Projects: GA ČR(CZ) GA19-09212S
Institutional support: RVO:68081707
Keywords : Acute radiation syndrome * Bone marrow cells * Hematopoiesis * g-csf * Nitrooleic acid
OECD category: Pharmacology and pharmacy
Impact factor: 6.1, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0024320522008062?via%3Dihub

Aims: Limited number of agents that provide protection against hematopoietic acute radiation syndrome led us to the evaluation of nitro-oleic acid (NO(2)OA) as a potential protector/mitigator against radiation-induced hematopoietic injury in C57/BL6 mice. Materials and methods: NO(2)OA was administered before and after sub-lethal total body irradiation (TBI) and hematological parameters were evaluated 3 or 7 days after TBI. Key findings: Our results show that NO(2)OA significantly increase bone marrow cellularity including the granulocyte-macrophage colony-forming cells and erythroid progenitors on the 3rd day after TBI. In addition, NO(2)OA enhanced recovery of white blood cells (lymphocytes, neutrophils, and monocytes) in peripheral blood 7 days after irradiation. These effects may be in part attributed to NO(2)OA-induced granulocyte colony-stimulating factor production after TBI. On the other hand, radiation-induced impairment of peripheral red blood cells, hemoglobin, and platelets were not affected with NO(2)OA treatment up to 7 days post TBI. Significance: In conclusion, our data show that NO(2)OA significantly protects hematopoiesis after irradiation, and thus showed a high potential to act as an agent for medical radiation countermeasure.
Permanent Link: https://hdl.handle.net/11104/0336891