Measurement of Liver Stiffness using Atomic Force Microscopy Coupled with Polarization Microscopy

0564532 - ÚMG 2023 RIV US eng J - Journal Article
Ojha, Srikant - Přibyl, J. - Klimovič, Š. - Hadraba, Daniel - Jiroušková, Markéta - Gregor, Martin
Measurement of Liver Stiffness using Atomic Force Microscopy Coupled with Polarization Microscopy.
Jove-Journal of Visualized Experiments. Roč. 20, č. 185 (2022), č. článku e63974. ISSN 1940-087X
R&D Projects: GA ČR GA18-02699S; GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA MŠMT LX22NPO5102
Research Infrastructure: CIISB II - 90127
Institutional support: RVO:68378050 ; RVO:67985823
Keywords : Magnetic resonance elastography * Mr elastgraphy * Mechanical properties * Rat-liver * Fibrosis * Identation * Homeostasis * Diagnosis * Model
OECD category: Cell biology; Cell biology (FGU-C)
Impact factor: 1.2, year: 2022
Method of publishing: Open access
https://www.jove.com/t/63974/measurement-liver-stiffness-using-atomic-force-microscopy-coupled

Matrix stiffening has been recognized as one of the key drivers of the progression of liver fibrosis. It has profound effects on various aspects of cell behavior such as cell function, differentiation, and motility. However, as these processes are not homogeneous throughout the whole organ, it has become increasingly important to understand changes in the mechanical properties of tissues on the cellular level.
Permanent Link: https://hdl.handle.net/11104/0336325