Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine

0564327 - ÚSMH 2023 RIV DE eng J - Journal Article
Purikova, O. - Tkachenko, I. - Šmíd, B. - Veltruská, K. - Dinhová, T.N. - Vorokhta, Maryna - Kopecký, Jr., V. - Hanyková, L. - Ju, X.
Free-Blockage Mesoporous Silica Nanoparticles Loaded with Cerium Oxide as ROS-Responsive and ROS-Scavenging Nanomedicine.
Advanced Functional Materials. Roč. 32, č. 46 (2022), č. článku 2208316. ISSN 1616-301X. E-ISSN 1616-3028
Institutional support: RVO:67985891
Keywords : cerium oxide nanoparticles * drug delivery systems * free-blockages * mesoporous silica nanoparticles * ROS-responsiveness
OECD category: Medicinal chemistry
Impact factor: 19, year: 2022
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202208316

Mesoporous silica nanoparticles (MSNs) with reactive oxygen species (ROS)-responsive nanogate as drug delivery platforms are extensively investigated for biomedical applications. However, the physical blockages used to control the cargo release are often limited by their poor sealing ability and low biocompatibility. Herein, a design of free-blockage MSNs with methylthiopropyl units is proposed as the ROS-responsive switch. Four synthetic routes are compared with different precursors through either co-condensation or grafting methods to achieve the methylthio-functionalized MSNs. The quantity, localization, and chemical structure of the functional units, as well as the mesoporous structure of the silica can be tuned by optimizing the synthetic pathways to obtain desired final products. The ROS-responsive methylthiopropyl groups can be oxidized to sulfoxides in response to the presence of H2O2, leading to the hydrophobic/hydrophilic conversion of the MSNs. As a proof-of-concept design, ultrasmall cerium oxide nanoparticles are encapsulated into the functionalized MSNs and released out within 10 min scavenging more than 80% of the H2O2 in an ROS-rich environment. This study provides a novel design of a free-blockage ROS-controlled release system loaded with ROS-scavenging nanoparticles for the future application of targeted drug delivery systems combined with antioxidant therapy.
Permanent Link: https://hdl.handle.net/11104/0340357