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Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes
- 1.0562673 - MBÚ 2023 RIV US eng J - Journal Article
Klímová, Nela - Holubová, Jana - Streparola, Gaia - Tomala, Jakub - Brázdilová, Ludmila - Staněk, Ondřej - Bumba, Ladislav - Šebo, Peter
Pertussis toxin suppresses dendritic cell-mediated delivery of B. pertussis into lung-draining lymph nodes.
PLoS Pathogens. Roč. 18, č. 6 (2022), č. článku e1010577. ISSN 1553-7366. E-ISSN 1553-7374
R&D Projects: GA ČR(CZ) GX19-27630X; GA ČR(CZ) GA22-23578S; GA MŠMT(CZ) LM2018133; GA MŠMT(CZ) ED1.1.00/02.0109
Research Infrastructure: Czech-BioImaging II - 90129; EATRIS-CZ III - 90133
Institutional support: RVO:61388971 ; RVO:86652036
Keywords : adenylate-cyclase toxin * respiratory-tract colonization * bordetella-pertussis * neutrophil * recruitment * antigen presentation * adp-ribosylation * immune-response * rtx proteins * in-vitro * infection
OECD category: Microbiology
Impact factor: 6.7, year: 2022
Method of publishing: Open access
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010577
Author summaryOf the three classical Bordetella species causing respiratory infections in mammals, only the human-specialized whooping cough agent B. pertussis produces the pertussis toxin (PT) as its major virulence factor. Human pertussis is an acute respiratory illness and the pleiotropic activities of pertussis toxin account for the characteristic systemic manifestations of the disease, such as hyperleukocytosis, histamine sensitization, hyperinsulinemia, or inflammatory lung pathology. We found that PT activity inhibits the migration of infected dendritic cells from the lungs into the draining mediastinal lymph nodes (mLNs). This prevents mLN infection by bacteria evading from migratory cells and delivery of bacterial antigens into mLNs. As a result, the induction of adaptive serum antibody responses to infection is delayed. We thus propose that PT action serves to create a time window for proliferation of B. pertussis on airway mucosa to facilitate transmission of the pathogen among humans.
Permanent Link: https://hdl.handle.net/11104/0334929
Number of the records: 1