gamma-Tubulin in microtubule nucleation and beyond

0562229 - ÚMG 2023 RIV CH eng J - Journal Article
Sulimenko, Vadym - Dráberová, Eduarda - Dráber, Pavel
gamma-Tubulin in microtubule nucleation and beyond.
Frontiers in Cell and Developmental Biology. Roč. 10, Sep 1 (2022), č. článku 880761. ISSN 2296-634X. E-ISSN 2296-634X
R&D Projects: GA ČR GA21-30281S; GA MŠMT LTAUSA19118; GA MŠMT LX22NPO5102
Institutional support: RVO:68378050
Keywords : microtubule nucleation * alpha beta-tubulin dimer * gamma-tubulin functions * gamma-tubulin isotypes * gamma-tubulin ring complexes (gamma-TuRC)
OECD category: Cell biology
Impact factor: 5.5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fcell.2022.880761

Microtubules composed of alpha betatubulin dimers are dynamic cytoskeletal polymers that play key roles in essential cellular processes such as cell division, organelle positioning, intracellular transport, and cell migration. gammaTubulin is a highly conserved member of the tubulin family that is required for microtubule nucleation. gammaTubulin, together with its associated proteins, forms the gammatubulin ring complex (gammaTuRC), that templates microtubules. Here we review recent advances in the structure of gammaTuRC, its activation, and centrosomal recruitment. This provides new mechanistic insights into the molecular mechanism of microtubule nucleation. Accumulating data suggest that gammatubulin also has other, less well understood functions. We discuss emerging evidence that gammatubulin can form oligomers and filaments, has specific nuclear functions, and might be involved in centrosomal cross-talk between microtubules and microfilaments.
Permanent Link: https://hdl.handle.net/11104/0338205