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Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm
- 1.0562057 - ÚEB 2023 RIV GB eng J - Journal Article
Yang, M. - Özdemir, Zülal - Kim, H. - Nah, S. - Andris, Erik - Li, X. - Wimmer, Zdeněk - Yoon, J.-N.
Acid-Responsive Nanoporphyrin Evolution for Near-Infrared Fluorescence-Guided Photo-Ablation of Biofilm.
Advanced Healthcare Materials. Roč. 11, č. 14 (2022), č. článku 2200529. ISSN 2192-2640. E-ISSN 2192-2659
R&D Projects: GA MPO(CZ) FV10599; GA MŠMT(CZ) EF16_019/0000729
Grant - others:AVČR(CZ) VAJVA-19-48
Research Infrastructure: e-INFRA CZ - 90140
Institutional support: RVO:61389030 ; RVO:61388963
Keywords : acid-responsive nanoporphyrin * MRSA biofilms * NIR fluorescence * phototherapy * structural evolution
OECD category: Organic chemistry
Impact factor: 10, year: 2022
Method of publishing: Limited access
https://doi.org/10.1002/adhm.202200529
Combating biofilm infections remains a challenge due to the shield and acidic conditions. Herein, an acid-responsive nanoporphyrin (PN3-NP) based on the self-assembly of a water-soluble porphyrin derivative (PN3) is constructed. Additional kinetic control sites formed by the conjugation of the spermine molecules to a porphyrin macrocycle make PN3 self-assemble into stable nanoparticles (PN3-NP) in the physiological environment. Noteworthily, near-infrared (NIR) fluorescence monitoring and synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) effects of PN3-NP can be triggered by the acidity in biofilms, accompanied by intelligent transformation into dot-like nanospheres. Thus, damage to normal tissue is effectively avoided and accurate diagnosis and treatment of biofilms is achieved successfully. The good results of fluorescence imaging-guided photo-ablation of antibiotic-resistant strains methicillin-resistant Staphylococcus aureus (MRSA) biofilms verify that PN3-NP is a promising alternative to antibiotics. Meanwhile, this strategy also opens new horizons to engineer smart nano-photosensitizer for accurate diagnosis and treatment of biofilms.
Permanent Link: https://hdl.handle.net/11104/0334475
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