Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor

0561869 - ÚCHP 2023 RIV GB eng J - Journal Article
Sauer, L. - Kralik, D. - Izák, Pavel - Slouka, Z. - Přibyl, M.
Effects of aqueous systems and stabilization membranes on the separation of an antibiotic precursor in a microextractor.
Separation and Purification Technology. Roč. 292, JUL 1 (2022), č. článku 121050. ISSN 1383-5866. E-ISSN 1873-3794
R&D Projects: GA ČR(CZ) GA20-09980S
Institutional support: RVO:67985858
Keywords : microextractor * membrane separation * aqueous two-phase system * mass transport
OECD category: Chemical process engineering
Impact factor: 8.6, year: 2022
Method of publishing: Open access with time embargo

Small-scale, continuous separation and purification of fine chemicals of pharmaceutical value represent a challenging engineering task. Currently available slug-flow and parallel-flow microfluidic extractors suffer from instabilities of the liquid-liquid interface and difficult realization of the counter-current arrangement. To tackle this challenge, we constructed a robust microfluidic membrane extractor, which was realized as a membrane tube-in-a-shell system operating in a wide range of extraction conditions. We tested the microextractor performance on separating 7-aminodeacetoxycephalosporanic acid (7-ADCA), an essential precursor of beta-lactam antibiotics. Aqueous two-phase system (ATPS) and a system of identical aqueous phases were used in a series of extraction experiments. Expectedly, we found that the counter-current arrangement provides an almost 100 % yield of 7-ADCA. The enhanced 7-ADCA enrichment anticipated in the selected ATPS thanks to favorable 7-ADCA partitioning was only reached at longer residence times. Lower mass transport resistances occurring in low viscous aqueous phases turned out to have a primary effect on the extraction characteristics. A detailed analysis of transport resistances also revealed that the contribution of the tubular membrane to the overall mass transport resistance is low. This important finding indicates that microcontactors with thin integrated membranes are a promising option for micro-or milli-plants when fine chemicals are continuously produced.
Permanent Link: https://hdl.handle.net/11104/0334333