Multiple Roles of SMC5/6 Complex during Plant Sexual Reproduction

0561410 - ÚEB 2023 RIV CH eng J - Journal Article
Yang, Fen - Pečinka, Aleš
Multiple Roles of SMC5/6 Complex during Plant Sexual Reproduction.
International Journal of Molecular Sciences. Roč. 23, č. 9 (2022), č. článku 4503. E-ISSN 1422-0067
R&D Projects: GA ČR(CZ) GA22-00871S
Institutional support: RVO:61389030
Keywords : fertility * genome stability * meiosis * polyploidy * reproductive development * seed * SMC5/6 complex
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://doi.org/10.3390/ijms23094503

Chromatin-based processes are essential for cellular functions. Structural maintenance of chromosomes (SMCs) are evolutionarily conserved molecular machines that organize chromosomes throughout the cell cycle, mediate chromosome compaction, promote DNA repair, or control sister chromatid attachment. The SMC5/6 complex is known for its pivotal role during the maintenance of genome stability. However, a dozen recent plant studies expanded the repertoire of SMC5/6 complex functions to the entire plant sexual reproductive phase. The SMC5/6 complex is essential in meiosis, where its activity must be precisely regulated to allow for normal meiocyte development. Initially, it is attenuated by the recombinase RAD51 to allow for efficient strand invasion by the meiosis-specific recombinase DMC1. At later stages, it is essential for the normal ratio of interfering and non-interfering crossovers, detoxifying aberrant joint molecules, preventing chromosome frag-mentation, and ensuring normal chromosome/sister chromatid segregation. The latter meiotic defects lead to the production of diploid male gametes in Arabidopsis SMC5/6 complex mutants, increased seed abortion, and production of triploid offspring. The SMC5/6 complex is directly involved in controlling normal embryo and endosperm cell divisions, and pioneer studies show that the SMC5/6 complex is also important for seed development and normal plant growth in cereals.
Permanent Link: https://hdl.handle.net/11104/0334034