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If Mendel Was Using CRISPR: Genome Editing Meets Non-Mendelian Inheritance
- 1.0561342 - BFÚ 2023 RIV DE eng J - Journal Article
Hudzieczek, Vojtěch - Hobza, Roman - Cápal, Petr - Šafář, Jan - Doležel, Jaroslav
If Mendel Was Using CRISPR: Genome Editing Meets Non-Mendelian Inheritance.
Advanced Functional Materials. Roč. 32, č. 37 (2022), č. článku 2202585. ISSN 1616-301X. E-ISSN 1616-3028
R&D Projects: GA ČR(CZ) GA22-05478S; GA ČR(CZ) GA22-00204S; GA MŠMT(CZ) EF16_019/0000827
Institutional support: RVO:68081707 ; RVO:61389030
Keywords : crop improvement * epigenomes * gene mutations * genome editing * Gregor Mendel * organellar genomes * targeted chromosomal rearrangements
OECD category: Plant sciences, botany; Plant sciences, botany (UEB-Q)
Impact factor: 19, year: 2022
Method of publishing: Limited access
https://onlinelibrary.wiley.com/doi/10.1002/adfm.202202585
On July 20 this year, 200th anniversary of the birth of Gregor Mendel, an Augustinian monk who laid the foundations of genetics, is celebrated. His findings provided the stepping stone for rational crop improvement based on cross breeding and selection. While this approach contributed to the development of superior varieties, its potential is limited by genetic variability available within a species and its relatives. Even though physical and chemical mutagenesis enabled the induction of new genetic variability on a large scale, random mutagenesis did not allow targeting particular genome loci. This became feasible only after the development of genome editing tools in the beginning of the 21st century and the ability to precisely edit plant genomes opened a new era in plant research and crop breeding. Mendel probably did not consider a possibility of directly modifying genetic information and the advantages which genetic engineering can bring to society. However, the basic principles of inheritance he discovered are indispensable for any effort to develop improved varieties. In this review, recent advances in plant genome editing are summarized with emphasis on non-Mendelian inheritance in the light of the need to produce more food for the growing human population.
Permanent Link: https://hdl.handle.net/11104/0340744
Number of the records: 1