Alteration of phospholipases C and cholesterol transporters response is induced by subchronic inhalation of lead oxide nanoparticles

0561116 - ÚIACH 2023 GR eng A - Abstract
Mikuška, Pavel - Dumková, J. - Kristeková, Daniela - Vrlíková, Lucie - Jedličková, Adriena - Alexa, Lukáš - Večeřa, Zbyněk - Křůmal, Kamil - Coufalík, Pavel - Laštovičková, Markéta - Hampl, A. - Buchtová, Marcela
Alteration of phospholipases C and cholesterol transporters response is induced by subchronic inhalation of lead oxide nanoparticles.
11th International Aerosol Conference. Athens: The Hellenic Association for Aerosol Research, 2022. s. 88-88, č. článku AH-P1-008..
[International Aerosol Conference 2022 /11./. 04.09.2022-09.09.2022, Athens]
R&D Projects: GA ČR(CZ) GA20-02203S
Institutional support: RVO:68081715
Keywords : nanoparticle * mouse * toxicity
OECD category: Analytical chemistry

We investigated in detail macrophages as specialized cells involved in the innate and adaptive immune response in selected target mice organs to unravel their potential involvement in reaction to subchronic PbO nanoparticle inhalation. We also tackled possible alterations in lipid uptake in the lungs and liver, which is usually associated with foam macrophage formation.
Permanent Link: https://hdl.handle.net/11104/0333804