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Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse
- 1.0561062 - BTÚ 2023 RIV GB eng J - Journal Article
Blaha, J. - Skálová, Tereza - Kalousková, B. - Skořepa, O. - Cmunt, D. - Grobárová, V. - Pažický, S. - Polachova, E. - Abreu, C. - Stránský, Jan - Koval, Tomáš - Dušková, Jarmila - Zhao, Y. - Harlos, K. - Hašek, Jindřich - Dohnálek, Jan - Vaněk, O.
Structure of the human NK cell NKR-P1:LLT1 receptor:ligand complex reveals clustering in the immune synapse.
Nature Communications. Roč. 13, č. 1 (2022), č. článku 5022. E-ISSN 2041-1723
R&D Projects: GA ČR(CZ) GA15-15181S; GA ČR(CZ) GA18-10687S; GA MŠMT EF15_003/0000447; GA MŠMT(CZ) LM2018127
Institutional support: RVO:86652036
Keywords : HIGH-LEVEL EXPRESSION * TRANSCRIPT 1 LLT1 * T-CELLS
OECD category: Immunology
Impact factor: 16.6, year: 2022
Method of publishing: Open access
https://www.nature.com/articles/s41467-022-32577-6
NKR-P1 is an inhibitory receptor on the surface of natural killer cells, and its engagement with the ligand LLT1 on activated monocytes and B cells triggers NK cell self-tolerance and other immunological processes. Here authors set up a comprehensive, structure-based model of NKR-P1-LLT1 interaction that involves NKR-P1 homodimer formation and subsequent bridging of two LLT1 molecules.
Permanent Link: https://hdl.handle.net/11104/0340821
Number of the records: 1