Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

0560832 - ÚEM 2023 RIV CH eng J - Journal Article
Mukherjee, S. - Bartoš, O. - Zdeňková, K. - Hanák, Petr - Horká, P. - Musilová, Z.
Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication.
Fishes. Roč. 6, č. 4 (2021), č. článku 70. E-ISSN 2410-3888
Institutional support: RVO:68378041
Keywords : parvalbumin * fish * molecular evolution * allergenicity * fish allergy * genome duplication
OECD category: Genetics and heredity (medical genetics to be 3)
Impact factor: 3.170, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2410-3888/6/4/70

Parvalbumin is considered a major fish allergen. Here, we report the molecular evolution of the parvalbumin genes in bony fishes based on 19 whole genomes and 70 transcriptomes. We found unexpectedly high parvalbumin diversity in teleosts, three main gene types (pvalb-alpha, pvalb-beta 1, and pvalb-beta 2, including oncomodulins) originated at the onset of vertebrates. Teleosts have further multiplied the parvalbumin gene repertoire up to nine ancestral copies-two copies of pvalb-alpha, two copies of pvalb-beta 1, and five copies of pvalb-beta 2. This gene diversity is a result of teleost-specific whole-genome duplication. Two conserved parvalbumin genomic clusters carry pvalb-beta 1 and beta 2 copies, whereas pvalb-alpha genes are located separately in different linkage groups. Further, we investigated parvalbumin gene expression in 17 tissues of the common carp (Cyprinus carpio), a species with 21 parvalbumin genes in its genome. Two pvalb-alpha and eight pvalb-beta 2 copies are highly expressed in the muscle, while two alternative pvalb-alpha copies show expression in the brain and the testes, and pvalb-beta 1 is dominant in the retina and the kidney. The recent pairs of muscular pvalb-beta 2 genes show differential expression in this species. We provide robust genomic evidence of the complex evolution of the parvalbumin genes in fishes.
Permanent Link: https://hdl.handle.net/11104/0333734