Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism

0560656 - ÚJF 2023 RIV GB eng J - Journal Article
Kundrát, Pavel - Pachnerová Brabcová, Kateřina - Jelínek Michaelidesová, Anna - Zahradníček, Oldřich - Danilova, Irina - Štěpán, Václav - Jamborová, Zuzana - Davídková, Marie
Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism.
Radiation Protection Dosimetry. Roč. 198, 9-11 (2022), s. 527-531. ISSN 0144-8420. E-ISSN 1742-3406
R&D Projects: GA ČR(CZ) GA21-06451S
Institutional support: RVO:61389005
Keywords : proton radiotherapy * B-11, B-10 reactions * effectiveness of Boron
OECD category: Biophysics
Impact factor: 1, year: 2022
Method of publishing: Limited access
https://doi.org/10.1093/rpd/ncac093

Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the underlying physical processes involve the nuclear reaction of B-11 with protons or B-10 with secondary neutrons, both producing densely ionizing short-ranged particles. Likewise, potential roles of intercellular communication or boron acting as a radiosensitizer are not clear. We present an ongoing research project based on a multiscale approach to elucidate the mechanism by which boron enhances the effectiveness of proton irradiation in the Bragg peak. It combines experimental with simulation tools to study the physics of proton-boron interactions, and to analyze intra- and inter-cellular boron biology upon proton irradiation.
Permanent Link: https://hdl.handle.net/11104/0333518