Use of metal nanoparticles for preconcentration and analysis of biological thiols

0560185 - ÚIACH 2024 RIV DE eng J - Journal Article
Itterheimová, Petra - Dosedělová, Věra - Kubáň, Petr
Use of metal nanoparticles for preconcentration and analysis of biological thiols.
Electrophoresis. Roč. 44, 1-2 (2023), s. 135-157. ISSN 0173-0835. E-ISSN 1522-2683
R&D Projects: GA ČR(CZ) GA22-23815S
Institutional support: RVO:68081715
Keywords : biological thiols * electrochemical methods * nanoparticles * optical methods * separation methods
OECD category: Analytical chemistry
Impact factor: 2.9, year: 2022
Method of publishing: Limited access

Metal nanoparticles (NPs) exhibit several unique physicochemical properties, including redox activity, surface plasmon resonance, ability to quench fluorescence, biocompatibility, or a high surface-to-volume ratio. They are being increasingly used in analysis and preconcentration of thiol containing compounds, because they are able to spontaneously form a stable Au/Ag/Cu-S dative bond. They thus find wide application in environmental and particularly in medical science, especially in the analysis of biological thiols, the endogenous compounds that play a significant role in many biological systems. In this review article, we provide an overview of various types of NPs that have been applied in analysis and preconcentration of biological thiols, mainly in human biological fluids. We first discuss shortly the types of NPs and their synthesis, properties, and their ability to interact with thiol compounds. Then we outline the sample preconcentration and analysis methods that were used for this purpose with special emphasis on optical, electrochemical, and separation techniques.
Permanent Link: https://hdl.handle.net/11104/0333193