Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms

0560073 - FZÚ 2023 RIV GB eng J - Journal Article
Jirát, J. - Babor, M. - Ridvan, L. - Skořepová, Eliška - Dušek, Michal - Šoóš, M.
Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms.
IUCrJ. Roč. 9, č. 4 (2022), s. 508-515. ISSN 2052-2525. E-ISSN 2052-2525
Institutional support: RVO:68378271
Keywords : apremilast * structure-property relations * multicomponent forms * equilibrium solubility * bioavailability
OECD category: Condensed matter physics (including formerly solid state physics, supercond.)
Impact factor: 3.9, year: 2022
Method of publishing: Open access

The structure–property relations are examined for apremilast cocrystals and solvates in this work. A unique and large dataset of multicomponent crystal forms is presented including 7 cocrystals and 12 solvates. In total, 15 of the presented multicomponent forms and their crystal structures are published here for the first time. This dataset is unique owing to the extreme crystal packing similarity of all 19 crystal forms. This fact makes the evaluation of structure–property relations significantly easier and more precise since the differences in the crystal lattice arrangement are close to negligible.

Permanent Link: https://hdl.handle.net/11104/0333623