Number of the records: 1
Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins
- 1.0559934 - ÚMG 2023 RIV CH eng J - Journal Article
Jakovljevic, A. - Tucic, M. - Blažíková, Michaela - Korenic, A. - Missirlis, Y. F. - Stamenkovic, V. - Andjus, P.
Structural and Functional Modulation of Perineuronal Nets: In Search of Important Players with Highlight on Tenascins.
Cells. Roč. 10, č. 6 (2021), č. článku 1345. ISSN 2073-4409. E-ISSN 2073-4409
R&D Projects: GA MŠMT(CZ) LM2018129; GA MŠMT(CZ) EF18_046/0016045; GA MŠMT LO1220; GA MŠMT LO1419
Institutional support: RVO:68378050
Keywords : extracellular matrix * perineuronal nets * tenascin-C * synaptic plasticity * mechanotransduction * neurogenesis * super-resolution microscopy
OECD category: Cell biology
Impact factor: 7.666, year: 2021
Method of publishing: Open access
https://www.mdpi.com/2073-4409/10/6/1345
The extracellular matrix (ECM) of the brain plays a crucial role in providing optimal conditions for neuronal function. Interactions between neurons and a specialized form of ECM, perineuronal nets (PNN), are considered a key mechanism for the regulation of brain plasticity. Such an assembly of interconnected structural and regulatory molecules has a prominent role in the control of synaptic plasticity. In this review, we discuss novel ways of studying the interplay between PNN and its regulatory components, particularly tenascins, in the processes of synaptic plasticity, mechanotransduction, and neurogenesis. Since enhanced neuronal activity promotes PNN degradation, it is possible to study PNN remodeling as a dynamical change in the expression and organization of its constituents that is reflected in its ultrastructure. The discovery of these subtle modifications is enabled by the development of super-resolution microscopy and advanced methods of image analysis.
Permanent Link: https://hdl.handle.net/11104/0333054
Number of the records: 1