Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses

0559903 - ÚOCHB 2023 RIV eng P - Patent Document
Veselovská, Lucia - Hocek, Michal - Hajdúch, M. - Džubák, P.
Substituted pyridopyrrolopyrimidine ribonucleosides for therapeutic uses.
2022. Owner: Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci. Date of the patent acceptance: 12.04.2022. Patent Number: US11299510
R&D Projects: GA ČR(CZ) GA16-00178S; GA TA ČR(CZ) TE01020028; GA MZd(CZ) NV15-31984A; GA MŠMT(CZ) EF16_019/0000729
Institutional support: RVO:61388963
Keywords : nucleosides * fused heterocycles * cytostatics
OECD category: Medicinal chemistry
https://worldwide.espacenet.com/patent/search/family/065763222/publication/US11299510B2?q=US11299510B2

Substituted pyridopyrrolopyrimidine ribonucleosides of general formula I, wherein R is as described in the independent claim, preferably R is selected from the group comprising thiophen-3-yl, furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines of tumor origin in a wide variety of diseases including tumors of different histogenetic origin.
Permanent Link: https://hdl.handle.net/11104/0333030