Improving microalgae for biotechnology From genetics to synthetic biology Moving forward but not there yet

0559848 - MBÚ 2023 RIV US eng J - Journal Article
Kselíková, Veronika - Singh, Anjali - Bialevich, Vitali - Čížková, Mária - Bišová, Kateřina
Improving microalgae for biotechnology From genetics to synthetic biology Moving forward but not there yet.
Biotechnology Advances. Roč. 58, SEP2022 (2022), č. článku 107885. ISSN 0734-9750. E-ISSN 1873-1899
R&D Projects: GA ČR(CZ) GA19-12607S
EU Projects: European Commission(CZ) 887227
Institutional support: RVO:61388971
Keywords : Algae * Mutagenesis * Genetic engineering * Ethyl methanesulfonate * UV irradiation * Biofuel * Photosynthesis * Carbon concentrating mechanism * Ribulose-1,5-bisphosphate carboxylase/oxygenase * Mutant library * Genome * Carotenoid * Astaxanthin
OECD category: Microbiology
Impact factor: 16, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0734975021001919?via%3Dihub

Microalgae are a diverse group of photosynthetic organisms that can be exploited for the production of different compounds, ranging from crude biomass and biofuels to high value-added biochemicals and synthetic proteins. Traditionally, algal biotechnology relies on bioprospecting to identify new highly productive strains and more recently, on forward genetics to further enhance productivity. However, it has become clear that further improvements in algal productivity for biotechnology is impossible without combining traditional tools with the arising molecular genetics toolkit. We review recent advantages in developing high throughput screening methods, preparing genome-wide mutant libraries, and establishing genome editing techniques. We discuss how algae can be improved in terms of photosynthetic efficiency, biofuel and high value-added compound production. Finally, we critically evaluate developments over recent years and explore future potential in the field.
Permanent Link: https://hdl.handle.net/11104/0334993