Animal models of cough

0559720 - ÚMG 2023 RIV NL eng J - Journal Article
Plevkova, J. - Brozmanova, M. - Matloobi, A. - Poliacek, I. - Honetschläger, Jan - Buday, T.
Animal models of cough.
Respiratory Physiology & Neurobiology. Roč. 290, August (2021), č. článku 103656. ISSN 1569-9048. E-ISSN 1878-1519
Institutional support: RVO:68378050
Keywords : Cough * Animal models * Reflex * Translation * Animal welfare
OECD category: Physiology (including cytology)
Impact factor: 2.821, year: 2021
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S1569904821000410?via%3Dihub

Cough is a vital airway reflex that keeps the respiratory tract wisely protected. It is also a sign of many diseases of the respiratory system and it may become a disease in its own right. Even though the efficacy of antitussive compounds is extensively studied in animal models with promising results, the treatment of pathological cough in humans is insufficient at the moment. The limited translational potential of animal models used to study cough causes, mechanisms and possible therapeutic targets stems from multiple sources. First of all, cough induced in the laboratory by mechanical or chemical stimuli is far from natural cough present in human disease.& nbsp, The main objective of this review is to provide a comprehensive summary of animal models currently used in cough research and to address their advantages and disadvantages. We also want to encourage cough researchers to call for precision is research by addressing the sex bias which has existed in basic cough research for decades and discuss the role of specific pathogen-free (SPF) animals.
Permanent Link: https://hdl.handle.net/11104/0332929