Ultrasound transmission tomography-guided heating with nanoparticles

0559550 - BC 2023 RIV GB eng J - Journal Article
Józefczak, A. - Opieliński, K.J. - Bielas, R. - Pruchnicki, P. - Bułkowski, M. - Jędrzak, A. - Šafařík, Ivo - Kopčanský, P.
Ultrasound transmission tomography-guided heating with nanoparticles.
Measurement. Roč. 197, June (2022), č. článku 111345. ISSN 0263-2241. E-ISSN 1873-412X
Institutional support: RVO:60077344
Keywords : contrast agents * magnetic nanoparticles * temperature measurement * ultrasound hyperthermia * ultrasound imaging * ultrasound transmission tomography
OECD category: Acoustics
Impact factor: 5.6, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0263224122005826?via%3Dihub

Nanoparticles can be used in numerous therapeutic procedures, including controlled drug delivery and release, thermal therapy, and photo- and sonodynamic therapy. However, such approaches remain limited due to difficulties associated with accurately controlling their therapeutic efficiency and localized consequences. Thus, we propose the use of ultrasound transmission tomography (UTT) measurements following ultrasonic heating when using nanomaterials as mediators. We test various nanomaterials doped to agar tissue-mimicking phantoms to study how they affect the UTT imaging through improving the contrast. Simultaneously, we investigate the suitability of these mediators in relation to the process of ultrasonic heating under the guidance of UTT. The results show that UTT is sensitive to the presence of magnetic nanoparticle-based nanomaterials and induced temperature rises. The combination of an imaging modality based on generally safe and well-known ultrasound-based imaging and the use of nanomaterials as mediators represents our proposal for a new theranostic approach.
Permanent Link: https://hdl.handle.net/11104/0336751