Are there differences in EEG between epileptic patients with vagal nerve stimulation (VNS) and healthy controls?

0559442 - ÚPT 2023 RIV US eng A - Abstract
Doležalová, I. - Koriťáková, E. - Chládek, Jan - Jurková, T. - Chrastina, J. - Jurák, Pavel - Brázdil, M.
Are there differences in EEG between epileptic patients with vagal nerve stimulation (VNS) and healthy controls?
European Journal of Neurology. Roč. 29, S1 (2022), s. 573-574. ISSN 1351-5101. E-ISSN 1468-1331.
[Congress of the European Academy of Neurology (EAN) /8./. 25.06.2022-28.06.2022, Vienna]
R&D Projects: GA MZd(CZ) NV19-04-00343
Institutional support: RVO:68081731
Keywords : EEG reactivity * epilepsy * vagal nerve stimulation * epilepsy treatment
OECD category: Neurosciences (including psychophysiology
https://onlinelibrary.wiley.com/doi/10.1111/ene.15466

Background and aims: The presented work is based on the results of our published work, in which we focused on the VNS efficacy prediction in patients with drug-resistant epilepsy. We found that there are differences in power spectra between VNS responders and non-responders. We asked two more questions. Are there differences between the epileptic patients with VNS and healthy controls? Do the EEG power spectra in healthy controls resemble more responders or non-responders to VNS therapy? Methods: We identified retrospectively EEG recording in epileptic patients with VNS and in healthy controls. The epileptic patients were classified based on the VNS efficacy as responder and non-responders EEG was segmented into several time-intervals (resting-state, eyes-opening 1, resting state, photic stimulation, hyperventilation, eyes opening 2, resting state 3 and resting state) and frequency bands. Subsequently, we established relative EEG power spectra in pre-defined frequency bands and time-intervals. Results: We identified EEG in 56 healthy controls and in 60 epileptic patients with VNS (35 responders, 25 non-responders). When compared healthy controls and epileptic patients, we identified EEG power spectra differences in theta (eyes-opening 1, 2), alpha (eyes-opening 1,2) and beta frequency range (eyes-opening 1). When compared responders to VNS therapy and healthy controls, we found more significant differences than in non-responders. Conclusion: There are differences in EEG power spectra between epileptic patients treated with VNS and healthy controls. These differences are present in more frequency bands and time-intervals. However, non-responders resemble healthy population more than responders. The question is whether we can employ these results for pre-implantation VNS prediction.
Permanent Link: https://hdl.handle.net/11104/0341013