Multiresponsive fluorinated polymers as a theranostic platform using 19F MRI

0559242 - ÚOCHB 2023 RIV GB eng J - Journal Article
Kolouchová, K. - Černochová, Z. - Groborz, Ondřej - Herynek, V. - Koucký, F. - Jaksa, R. - Beneš, J. - Šlouf, M. - Hrubý, M.
Multiresponsive fluorinated polymers as a theranostic platform using 19F MRI.
European Polymer Journal. Roč. 175, July (2022), č. článku 111381. ISSN 0014-3057. E-ISSN 1873-1945
R&D Projects: GA MŠMT(CZ) LM2018133
Research Infrastructure: Czech-BioImaging II - 90129
Institutional support: RVO:61388963
Keywords : thermoresponsive * ROS-responsive * stimuli-responsive * reactive oxygen species * fluorine * magnetic resonance imaging * drug delivery system * therapy * diagnostic
OECD category: Organic chemistry
Impact factor: 6, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.eurpolymj.2022.111381

Drug delivery systems (DDSs) can significantly improve the biodistribution and pharmacokinetics of various drugs. Herein, we describe diblock polymers of poly(2-methyloxazoline) and N-(2,2′-difluoroethyl)acrylamide with N-[2-(ferrocenylcarboxamido)ethyl]acrylamide that can be used as advanced DDSs. These thermoresponsive diblock copolymers self-assemble when heated to body temperature but disassemble when exposed to oxidative conditions (reactive oxygen species, ROS), releasing their cargo. Moreover, our polymers are not prone to spontaneous oxidation by air or hydrogen peroxide under physiological conditions but are highly sensitive to ROS under acidic conditions. Advantageously, the biodistribution of our DDS can be monitored with fluorine-19 magnetic resonance imaging (19F MRI). Therefore, our polymers could be used in both local and systemic drug delivery systems in ROS-rich environments, such as tumors or inflamed tissues. Additionally, the properties of our polymers could be widely modified to meet the demands of various clinical applications. Overall, we demonstrate that our copolymers (i) release their cargo preferentially in an ROS-rich environment, (ii) are biocompatible, and (iii) can be easily visualized in vivo.
Permanent Link: https://hdl.handle.net/11104/0332583