Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength

0559150 - ÚMCH 2023 RIV NL eng J - Journal Article
Dodda, J. M. - Azar, M. G. - Bělský, P. - Šlouf, Miroslav - Brož, Antonín - Bačáková, Lucie - Kadlec, J. - Remiš, T.
Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength.
Cellulose. Roč. 29, č. 12 (2022), s. 6697-6717. ISSN 0969-0239. E-ISSN 1572-882X
R&D Projects: GA ČR(CZ) GA20-01641S
Institutional support: RVO:61389013 ; RVO:67985823
Keywords : nulticomponent hydrogel * cellulose/starch * chitosan
OECD category: Polymer science; Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials (FGU-C)
Impact factor: 5.7, year: 2022
Method of publishing: Limited access
https://link.springer.com/article/10.1007/s10570-022-04686-4

Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings.
Permanent Link: https://hdl.handle.net/11104/0332755