The interactions between DNA nanostructures and cells: A critical overview from a cell biology perspective

0558817 - FZÚ 2023 RIV GB eng J - Journal Article
Frtús, Adam - Smolková, Barbora - Uzhytchak, Mariia - Lunova, Mariia - Jirsa, M. - Henry, S.J.W. - Dejneka, Alexandr - Stephanopoulos, N. - Lunov, Oleg
The interactions between DNA nanostructures and cells: A critical overview from a cell biology perspective.
Acta Biomaterialia. Roč. 146, July (2022), s. 10-22. ISSN 1742-7061. E-ISSN 1878-7568
R&D Projects: GA MŠMT(CZ) EF16_019/0000760
Grant - others:OP VVV - SOLID21(XE) CZ.02.1.01/0.0/0.0/16_019/0000760
Institutional support: RVO:68378271
Keywords : nanotechnology * DNA nanotechnology * cytotoxicity * cellular uptake * protein corona * bionano interactions
OECD category: Biophysics
Impact factor: 9.7, year: 2022
Method of publishing: Limited access
https://doi.org/10.1016/j.actbio.2022.04.046

DNA nanotechnology has yielded remarkable advances in composite materials with diverse applications in biomedicine. The specificity and predictability of building 3D structures at the nanometer scale make DNA nanotechnology a promising tool for uses in biosensing, drug delivery, cell modulation, and bioimaging. However, for successful translation of DNA nanostructures to real-world applications, it is crucial to understand how they interact with living cells, and the consequences of such interactions. In this review, we summarize the current state of knowledge on the interactions of DNA nanostructures with cells. We identify key challenges, from a cell biology perspective, that influence progress towards the clinical translation of DNA nanostructures.
Permanent Link: http://hdl.handle.net/11104/0332366