Number of the records: 1  

Silybin and its congeners: from traditional medicine to molecular effects

  1. 1.
    0558662 - MBÚ 2023 RIV GB eng J - Journal Article
    Křen, Vladimír - Valentová, Kateřina
    Silybin and its congeners: from traditional medicine to molecular effects.
    Natural Product Reports. Roč. 39, č. 6 (2022), s. 1264-1281. ISSN 0265-0568. E-ISSN 1460-4752
    R&D Projects: GA ČR GA21-00551S; GA MŠk(CZ) LTC20070
    Institutional support: RVO:61388971
    Keywords : milk thistle * silymarin flavonolignans * in-vitro * silibinin * silychristin * isosilybin * 2,3-dehydrosilybin * diastereoisomers * identification * derivatives
    OECD category: Medicinal chemistry
    Impact factor: 15.111, year: 2021
    Method of publishing: Limited access
    https://pubs.rsc.org/en/content/articlelanding/2022/NP/D2NP00013J

    Covering: 2015 up to 2022 (Feb) Silymarin, an extract of milk thistle (Silybum marianum) fruits, has been used in various medicinal applications since ancient times. A major component of silymarin is the flavonolignan silybin and its relatives isosilybin, silychristin, silydianin, 2,3-dehydrosilybin, and some others. Except for silydianin, they occur in nature as two stereomers. This review focuses on recent developments in chemistry, biosynthesis, modern advanced analytical methods, and transformations of flavonolignans specifically reflecting their chirality. Recently described chemotypes of S. marianum, but also the newest findings regarding the pharmacokinetics, hepatoprotective, antiviral, neuroprotective, and cardioprotective activity, modulation of endocrine functions, modulation of multidrug resistance, and safety of flavonolignans are discussed. A growing number of studies show that the respective diastereomers of flavonolignans have significantly different activities in anisotropic biological systems. Moreover, it is now clear that flavonolignans do not act as antioxidants in vivo, but as specific ligands of biological targets and therefore their chirality is crucial. Many controversies often arise, mainly due to the non-standard composition of this phytopreparation, the use of various undefined mixtures, the misattribution of silymarin vs. silybin, and also the failure to consider the chemistry of the respective components of silymarin.
    Permanent Link: https://hdl.handle.net/11104/0332537

     
     
Number of the records: 1