Number of the records: 1
Serpins in Tick Physiology and Tick-Host Interaction
- 1.0558626 - BC 2023 RIV CH eng J - Journal Article
Abbas, M. - Chlastáková, Adéla - Jmel, Mohamed Amine - Iliaki-Giannakoudaki, E. - Chmelař, J. - Kotsyfakis, Michalis
Serpins in Tick Physiology and Tick-Host Interaction.
Frontiers in Cellular and Infection Microbiology. Roč. 12, MAY 19 2022 (2022), č. článku 892770. ISSN 2235-2988. E-ISSN 2235-2988
R&D Projects: GA ČR(CZ) GA19-07247S; GA MŠMT(CZ) EF16_019/0000759; GA ČR(CZ) GM22-18424M
Institutional support: RVO:60077344
Keywords : serine proteinase-inhibitors * cross-class inhibitor * t-cell subsets * haemaphysalis-longicornis * boophilus-microplus * ixodes-scapularis * platelet-aggregation * complement-system * salivary protein * cathepsin-g * tick saliva * serpins * immunomodulation * therapeutic effects * anti-tick vaccine * tick host interaction
OECD category: Biochemistry and molecular biology
Impact factor: 5.7, year: 2022
Method of publishing: Open access
https://www.frontiersin.org/articles/10.3389/fcimb.2022.892770/full
Tick saliva has been extensively studied in the context of tick-host interactions because it is involved in host homeostasis modulation and microbial pathogen transmission to the host. Accumulated knowledge about the tick saliva composition at the molecular level has revealed that serine protease inhibitors play a key role in the tick-host interaction. Serpins are one highly expressed group of protease inhibitors in tick salivary glands, their expression can be induced during tick blood-feeding, and they have many biological functions at the tick-host interface. Indeed, tick serpins have an important role in inhibiting host hemostatic processes and in the modulation of the innate and adaptive immune responses of their vertebrate hosts. Tick serpins have also been studied as potential candidates for therapeutic use and vaccine development. In this review, we critically summarize the current state of knowledge about the biological role of tick serpins in shaping tick-host interactions with emphasis on the mechanisms by which they modulate host immunity. Their potential use in drug and vaccine development is also discussed.
Permanent Link: https://hdl.handle.net/11104/0338403
Number of the records: 1