0558563 - ÚCHP 2023 CZ eng K - Konferenční příspěvek (tuzemská konf.)
Kurfiřt, Martin
Deoxyfluorinated N-acetyllactosamines as carbohydrate-based probes for human galectins.
Proceedings of Abstracts. Prague: Institute of Chemical Process Fundamentals of the CAS, 2022 - (Bendová, M.; Wagner, Z.), s. 45-46. ISBN 978-80-86186-24-5.
[Bažant Postgraduate Conference 2022. Prague (CZ), 13.06.2022-14.06.2022]
Grant CEP: GA MŠMT(CZ) LTC20052; GA ČR(CZ) GA20-01472S
Grant ostatní: MEYS(XE) CA18103
Institucionální podpora: RVO:67985858
Klíčová slova: human galectins * NMR techniques * selective inhibitors
Obor OECD: Organic chemistry

This work is focused on a detailed NMR investigation of human galectins via a complete series of mono-deoxyfluorinated Nacetyllactosamine probes 1–6, which were prepared previously in our laboratory.3 Advanced 19F NMR T2-filter technique enabled the identification of hydroxyl groups essential for the interaction with varioushGals, and permitted to compare hGals in terms of the importance of these key hydroxyl groups in the recognition events. Furthermore, the library was also investigated by various NMR techniques such as 19F EXSY, STD and 15N CSP to reveal the molecular origin of recognition events.

Trvalý link: http://hdl.handle.net/11104/0332200