Possible involvement of apoptosis in the antipsychotics side effects: A mini-review

0558473 - ÚOCHB 2023 RIV AU eng J - Journal Article
Osacká, J. - Kiss, A. - Pirník, Zdenko
Possible involvement of apoptosis in the antipsychotics side effects: A mini-review.
Clinical and Experimental Pharmacology and Physiology. Roč. 49, č. 8 (2022), s. 836-847. ISSN 0305-1870. E-ISSN 1440-1681
Institutional support: RVO:61388963
Keywords : apoptosis * atypical antipsychotics * side effects * therapeutic effects * typical antipsychotics
OECD category: Pharmacology and pharmacy
Impact factor: 2.9, year: 2022
Method of publishing: Limited access
https://doi.org/10.1111/1440-1681.13671

Antipsychotics are used in the treatment of schizophrenia and other psychiatric disorders. Generally, they are divided into typical and atypical ones, according to the fact that atypical antipsychotics induce fewer side effects and are more effective in terms of social and cognitive improvements. Their pharmacological effects are mediated via broad range of receptors that consequently influence different cellular signalling pathways. Antipsychotics produce undesirable side effects that range from relatively minor to life threatening. In vitro and in vivo studies have pointed to neurotoxic effect exerted by some antipsychotics and have shown that apoptosis might play role in some side effects induced by antipsychotics, including tardive dyskinesia, weight gain, agranulocytosis, osteoporosis, myocarditis, etc. Although cumulative data have suggested safety of atypical antipsychotics use during pregnancy, some of them have been shown to induce apoptotic neurodegenerative and structural changes in fetal brains with long-lasting impact on cognitive impairment of offspring. Typical antipsychotics seem to be more cytotoxic than atypical ones. Recently, epidemiological studies have shown lower incidence of cancer in schizophrenic patients that suggest the ability of antipsychotics to suppress risk of cancer development. Some antipsychotics have been reported to inhibit cancer cell proliferation and induce their apoptosis. Therefore, antipsychotics apoptotic effect may be used as a tool in the treatment of some types of cancer, especially in combinatorial therapies. In this mini-review, we focused on pro- and antiapoptotic or 'Dr. Jekyll and Mr. Hyde' effects of antipsychotics, which can be involved in their side effects, as well as their promising therapeutic indications.
Permanent Link: http://hdl.handle.net/11104/0332120