Obesity II: Establishing causal links between chemical exposures and obesity

0558379 - BFÚ 2023 RIV US eng J - Journal Article
Heindel, J. J. - Howard, S. - Agay-Shay, K. - Arrebola, J. - Audouze, K. - Babin, P. - Barouki, R. - Bansal, A. - Blanc, E. - Cave, M. - Chatterjee, S. - Chevalier, N. - Choudhury, M. - Collier, D. - Connolly, L. - Coumoul, X. - Garruti, G. - Gilbertson, M. - Hoepner, L. - Holloway, A. K. - Howell Iii, G. - Kassotis, C. - Kay, M. - Kim, M. - Lagadic-Gossmann, D. - Langouet, S. - Legrand, A. - Li, Z. - Le Mentec, H. - Lind, A. L. - Vondráček, Jan … Total 43 authors
Obesity II: Establishing causal links between chemical exposures and obesity.
Biochemical Pharmacology. Roč. 199, MAY 2022 (2022), č. článku 115015. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR(CZ) GA21-00533S
Institutional support: RVO:68081707
Keywords : endocrine-disrupting chemicals * persistent organic pollutants * ambient air-pollution * organophosphate flame-retardants * activated-receptor-gamma * aryl-hydrocarbon receptor
OECD category: Pharmacology and pharmacy
Impact factor: 5.8, year: 2022
Method of publishing: Limited access
https://www.sciencedirect.com/science/article/pii/S0006295222001095?via%3Dihub

Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
Permanent Link: https://hdl.handle.net/11104/0340824