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Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects
- 1.0558031 - ÚOCHB 2023 RIV CH eng J - Journal Article
Krečmerová, Marcela - Majer, Pavel - Rais, R. - Slusher, B. S.
Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects.
Frontiers in Chemistry. Roč. 10, May (2022), č. článku 889737. ISSN 2296-2646. E-ISSN 2296-2646
R&D Projects: GA MŠMT(CZ) LM2018133
Institutional support: RVO:61388963
Keywords : acyclic nucleoside phosphonates * antivirals * prodrugs * protides * GCPII * prostate-specific membrane antigen * FOLH1 * 2-PMPA
OECD category: Organic chemistry
Impact factor: 5.5, year: 2022
Method of publishing: Open access
https://doi.org/10.3389/fchem.2022.889737
The review focus on biologically active phosphonates that originated from the IOCB Prague, i.e. acyclic nucleoside phosphonates, and derivatives of non-nucleoside phosphonates such as 2-(phosphonomethyl) pentanedioic acid (2-PMPA). Principal strategies of their syntheses and modifications to prodrugs is reported.
Permanent Link: http://hdl.handle.net/11104/0331849
Number of the records: 1