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SGK1 is essential for meiotic resumption in mammalian oocytes
- 1.0558029 - ÚŽFG 2023 RIV DE eng J - Journal Article
del Llano, Edgar - Iyyappan, Rajan - Aleshkina, Daria - Mašek, T. - Dvořan, Michal - Jiang, Z. - Pospíšek, M. - Kubelka, Michal - Šušor, Andrej
SGK1 is essential for meiotic resumption in mammalian oocytes.
European Journal of Cell Biology. Roč. 101, č. 2 (2022), č. článku 151210. ISSN 0171-9335. E-ISSN 1618-1298
R&D Projects: GA MŠMT EF15_003/0000460; GA ČR(CZ) GA19-13491S
Institutional support: RVO:67985904
Keywords : oocyte * MPF * CDK1
OECD category: Developmental biology
Impact factor: 6.6, year: 2022
Method of publishing: Open access
https://www.sciencedirect.com/science/article/pii/S0171933522000139?via%3Dihub
In mammalian females, oocytes are stored in the ovary and meiosis is arrested at the diplotene stage of prophase I. When females reach puberty oocytes are selectively recruited in cycles to grow, overcome the meiotic arrest, complete the first meiotic division and become mature (ready for fertilization). At a molecular level, the master regulator of prophase I arrest and meiotic resumption is the maturation-promoting factor (MPF) complex, formed by the active form of cyclin dependent kinase 1 (CDK1) and Cyclin B1. However, we still do not have complete information regarding the factors implicated in MPF activation.
Permanent Link: http://hdl.handle.net/11104/0332100
Number of the records: 1