Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors

0558000 - MBÚ 2023 RIV US eng J - Journal Article
Zachová, K. - Jemelková, J. - Kosztyu, P. - Ohyama, Y. - Takahashi, K. - Zadražil, J. - Orsag, J. - Matoušovic, K. - Galuszková, D. - Petejová, N. - Městecký, Jiří - Raška, M.
Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors.
Journal of the American Society of Nephrology. Roč. 33, č. 5 (2022), s. 908-917. ISSN 1046-6673. E-ISSN 1533-3450
Institutional support: RVO:61388971
Keywords : human mesangial cells * immune-complexes * charge-distribution * glycosylation * nephritis * immunoglobulins * proliferation * antibodies * deposits * disease * IgA nephropathy * galactose * immunoglobulin A * B lymphocytes * galactose-deficient IgA1 * immunology * immunoglobulin lambda chains
OECD category: Microbiology
Impact factor: 13.6, year: 2022
Method of publishing: Limited access
https://jasn.asnjournals.org/content/33/5/908

Significance StatementIgA nephropathy (IgAN) is associated with mesangial deposition of aberrantly glycosylated IgA1 containing ? light chains and the association of upper respiratory or digestive tract infection with macroscopic hematuria. We found that peripheral blood Gd-IgA1(+) cells from IgAN patients express predominantly ? light chains and CCR9 and CCR10, compared with healthy controls. Furthermore, Gd-IgA1(+) cell populations in peripheral blood are enriched with plasmablasts/plasma cells. Therefore, IgAN is associated with an increased number of migratory Gd-IgA1-?(+) cells predestined for homing to upper respiratory and digestive tract mucosal tissues, where their final maturation and Gd-IgA1-? secretion may be stimulated during upper respiratory or digestive tract infections.
Permanent Link: http://hdl.handle.net/11104/0331943